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カイダ ケンイチ
KAIDA Kenichi
海田 賢一 所属 埼玉医科大学 医学部 総合医療センター 脳神経内科 職種 教授 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | An antibody to the GM1/GalNAc-GD1a complex correlates with development of pure motor Guillain-Barré syndrome with reversible conduction failure |
| 掲載誌名 | 正式名：Journal of Neuroimmunology ISSNコード：01655728 |
| 巻・号・頁 | 254(1-2),141-145頁 |
| 著者・共著者 | Go Ogawa,Ken-Ichi Kaida,Motoi Kuwahara,Fumihiko Kimura,Keiko Kamakura,Susumu Kusunoki |
| 発行年月 | 2013/01 |
| 概要 | Antibodies to a ganglioside complex consisting of GM1 and GalNAc-GD1a (GM1/GalNAc-GD1a) are found in sera from patients with Guillain-Barré syndrome (GBS). To elucidate the clinical significance of anti-GM1/GalNAc-GD1a antibodies in GBS, clinical features of 58 GBS patients with IgG anti-GM1/GalNAc-GD1a antibodies confirmed by enzyme-linked immunosorbent assay and thin layer chromatography immunostaining were analyzed. Compared to GBS patients without anti-GM1/GalNAc-GD1a antibodies, anti-GM1/GalNAc-GD1a-positive patients more frequently had a preceding respiratory infection (n = 38, 66%, p.<0.01) and were characterized by infrequency of cranial nerve deficits (n = 9, 16%, p.<0.01) and sensory disturbances (n = 26, 45%, p.<0.01). Of the 28 anti-GM1/GalNAc-GD1a-positive patients for whom electrophysiological data were available, 14 had conduction blocks (CBs) at intermediate segments of motor nerves, which were not followed by evident remyelination. Eight of 10 bedridden cases were able to walk independently within one month after the nadir. These results show that the presence of anti-GM1/GalNAc-GD1a antibodies correlated with pure motor GBS characterized by antecedent |
| DOI | 10.1016/j.jneuroim.2012.09.005 |
| PMID | 23000056 |