カイダ　ケンイチ   KAIDA Kenichi   海田　賢一    所属   埼玉医科大学  医学部 総合医療センター　脳神経内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	C-terminals in the mouse branchiomotor nuclei originate from the magnocellular reticular formation
掲載誌名	正式名：Neuroscience Letters ISSNコード：03043940
巻・号・頁	548,137-142頁
著者・共著者	Toshiyasu Matsui,Yu Hongo,Yoshinori Haizuka,Kenichi Kaida,George Matsumura,Donna M. Martin,Yasushi Kobayashi
発行年月	2013/08
概要	Large cholinergic synaptic boutons called"C-terminals"contact motoneurons and regulate their excitability. C-terminals in the spinal somatic motor nuclei originate from cholinergic interneurons in laminae VII and X that express a transcription factor Pitx2. Cranial motor nuclei contain another type of motoneuron: branchiomotor neurons. Although branchiomotor neurons receive abundant C-terminal projections, the neural source of these C-terminals remains unknown. In the present study, we first examined whether cholinergic neurons express Pitx2 in the reticular formation of the adult mouse brainstem, as in the spinal cord. Although Pitx2-positive cholinergic neurons were observed in the magnocellular reticular formation and region around the central canal in the caudal medulla, none was present more rostrally in the brainstem tegmentum. We next explored the origin of C-terminals in the branchiomotor nuclei by using biotinylated dextran amine (BDA). BDA injections into the magnocellular reticular formation of the medulla and pons resulted in the labeling of numerous C-terminals in the branchiomotor nuclei: the ambiguous, facial, and trigeminal motor nuclei. Our results revealed that
DOI	10.1016/j.neulet.2013.05.063
PMID	23756176