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カイダ ケンイチ
KAIDA Kenichi
海田 賢一 所属 埼玉医科大学 医学部 総合医療センター 脳神経内科 職種 教授 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Refractory status epilepticus caused by Anti-NMDA receptor encephalitis that markedly improved following combination therapy with rituximab and cyclophosphamide |
| 掲載誌名 | 正式名：Internal Medicine ISSNコード：13497235 |
| 出版社 | Japanese Society of Internal Medicine |
| 巻・号・頁 | 54(2),209-213頁 |
| 著者・共著者 | Masato Kadoya,Hiroyuki Onoue,Akiko Kadoya,Katsunori Ikewaki,Kenichi Kaida |
| 発行年月 | 2015/01 |
| 概要 | We herein describe the case of a 48-year-old woman who presented with nonconvulsive status epilepticus refractory to antiepileptic drugs caused by anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis without any tumors. She developed nausea and psychiatric symptoms, followed by fever and an acute progressive disturbance of consciousness. On admission to our hospital, she presented with involuntary orofacial movements and central hypoventilation, and an electroencephalogram showed a generalized slow activity consistent with nonconvulsive status epilepticus. The patient’s drug-resistant status epilepticus markedly improved following second-line immunotherapy with rituximab and cyclophosphamide. Physicians should consider the early initiation of second-line therapy in certain cases of anti-NMDAR encephalitis. |
| DOI | 10.2169/internalmedicine.54.2047 |
| PMID | 25743014 |