カイダ　ケンイチ   KAIDA Kenichi   海田　賢一    所属   埼玉医科大学  医学部 総合医療センター　脳神経内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読なし
表題	ABCG2 variant has opposing effects on onset ages of Parkinson's disease and gout.
掲載誌名	正式名：Annals of clinical and translational neurology
巻・号・頁	2(3),302-6頁
著者・共著者	Hirotaka Matsuo,Hiroyuki Tomiyama,Wataru Satake,Toshinori Chiba,Hiroyuki Onoue,Yusuke Kawamura,Akiyoshi Nakayama,Seiko Shimizu,Masayuki Sakiyama,Manabu Funayama,Kenya Nishioka,Toru Shimizu,Kenichi Kaida,Keiko Kamakura,Tatsushi Toda,Nobutaka Hattori,Nariyoshi Shinomiya
発行年月	2015/03
概要	Uric acid (urate) has been suggested to play a protective role in Parkinson's disease onset through its antioxidant activity. Dysfunction of ABCG2, a high-capacity urate exporter, is a major cause for early-onset gout based on hyperuricemia. In this study, the effects of a dysfunctional ABCG2 variant (Q141K, rs2231142) were analyzed on the ages at onset of gout patients (N = 507) and Parkinson's disease patients (N = 1015). The Q141K variant hastened the gout onset (P = 0.0027), but significantly associated with later Parkinson's disease onset (P = 0.025). Our findings will be helpful for development of more effective prevention of Parkinson's disease.
DOI	10.1002/acn3.167
PMID	25815357