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カイダ ケンイチ
KAIDA Kenichi
海田 賢一 所属 埼玉医科大学 医学部 総合医療センター 脳神経内科 職種 教授 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Anti-TIF1-γ antibody and cancer-associated myositis |
| 掲載誌名 | 正式名：Neurology ISSNコード：1526632X |
| 出版社 | Lippincott Williams and Wilkins |
| 巻・号・頁 | 87(3),299-308頁 |
| 著者・共著者 | Ayumi Hida,Takenari Yamashita,Yuji Hosono,Manami Inoue,Kenichi Kaida,Masato Kadoya,Yusuke Miwa,Nobuyuki Yajima,Reika Maezawa,Satoko Arai,Kazuhiro Kurasawa,Kazuhiro Ito,Hiroyuki Shimada,Tomoko Iwanami,Masahiro Sonoo,Yuki Hatanaka,Shigeo Murayama,Ayumi Uchibori,Atsuro Chiba,Hitoshi Aizawa,Takayuki Momoo,Yoshiharu Nakae,Yasuhisa Sakurai,Yasushi Shiio,Hideji Hashida,Toshihiro Yoshizawa,Yoshio Sakiyama,Aya Oda,Kiyoharu Inoue,Sousuke Takeuchi,Nobue K. Iwata,Hidetoshi Date,Naoki Masuda,Takashi Mikata,Yasufumi Motoyoshi,Yoshikazu Uesaka,Meiko Hashimoto Maeda,Ran Nakashima,Shoji Tsuji,Shin Kwak,Tsuneyo Mimori,Jun Shimizu |
| 発行年月 | 2016/07 |
| 概要 | Objective: We aimed to analyze the clinical and histopathologic features of cancer-associated myositis (CAM) in relation to anti-transcriptional intermediary factor 1 γ antibody (anti-TIF1-γ-Ab), a marker of cancer association. Methods: We retrospectively studied 349 patients with idiopathic inflammatory myopathies (IIMs), including 284 patients with pretreatment biopsy samples available. For the classification of IIMs, the European Neuromuscular Center criteria were applied. Patients with CAM with (anti-TIF1-γ-Ab[+]CAM) and without anti-TIF1-γ-Ab (anti-TIF1-γ-Ab[-]CAM)were compared with patients with IIM without cancers within and beyond 3 years of myositis diagnosis. Results: Cancer was detected in 75 patients, of whom 36 (48%) were positive for anti-TIF1-γ-Ab. In anti-TIF1-γ-Ab(+) patients with CAM, cancers were detected within 1 year of myositis diagnosis in 35 (97%) and before 1 year of myositis diagnosis in 1. All the anti-TIF1-γ-Ab(+) patients with CAM satisfied the dermatomyositis (DM) criteria, including 2 possible DM sine dermatitis cases, and were characterized histologically by the presence of perifascicular atrophy, vacuolated fibers (VFs), and dense C5b-9 d |
| DOI | 10.1212/WNL.0000000000002863 |
| PMID | 27343066 |