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カイダ ケンイチ
KAIDA Kenichi
海田 賢一 所属 埼玉医科大学 医学部 総合医療センター 脳神経内科 職種 教授 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | IgG4 anti-neurofascin155 antibodies in chronic inflammatory demyelinating polyradiculoneuropathy: Clinical significance and diagnostic utility of a conventional assay |
| 掲載誌名 | 正式名：Journal of Neuroimmunology ISSNコード：18728421 |
| 出版社 | Elsevier B.V. |
| 巻・号・頁 | 301,16-22頁 |
| 著者・共著者 | Masato Kadoya,Kenichi Kaida,Haruki Koike,Hiroshi Takazaki,Hidenori Ogata,Kota Moriguchi,Jun Shimizu,Eiichiro Nagata,Shunya Takizawa,Atsuro Chiba,Ryo Yamasaki,Jun-ichi Kira,Gen Sobue,Katsunori Ikewaki |
| 発行年月 | 2016/12 |
| 概要 | We aimed to validate the diagnostic utility of enzyme-linked immunosorbent assay (ELISA) for the detection of anti-neurofascin (NF) 155 antibody in 191 patients with chronic inflammatory demyelinating polyneuropathy (CIDP). Human NF155-based ELISA clearly distinguished between anti-NF155 antibody-positive and -negative sera. Fifteen CIDP patients (8%) were IgG4 anti-human NF155 antibody-positive, which were confirmed by western blot, cell-based assay and immunohistochemical study. None of disease controls or healthy subjects had positive results. Clinical presentation of IgG4 anti-NF155 antibody-positive patients was consistent with those in previous reports. This ELISA combined with determination of the IgG4 subclass is useful in screening for anti-NF155 antibodies. |
| DOI | 10.1016/j.jneuroim.2016.10.013 |
| PMID | 27852440 |