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カイダ ケンイチ
KAIDA Kenichi
海田 賢一 所属 埼玉医科大学 医学部 総合医療センター 脳神経内科 職種 教授 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Cholesterol-added antigens can enhance antiglycolipid antibody activity: Application to antibody testing |
| 掲載誌名 | 正式名：Journal of Neuroimmunology ISSNコード：01655728 |
| 掲載区分 | 国外 |
| 出版社 | Elsevier BV |
| 巻・号・頁 | 356,577580-577580頁 |
| 著者・共著者 | Yu Hongo,Kenichi Kaida,Yukari Komuta,Hiroshi Takazaki,Keishi Yamazaki,Kazushi Suzuki |
| 発行年月 | 2021/07 |
| 概要 | We analysed the effect of adding cholesterol to glycolipid antigens on antibody activity with enzyme-linked immunosorbent assay in 123 subjects consisting of 96 patients with Guillain-Barré syndrome, 25 Miller Fisher syndrome, and two Bickerstaff brainstem encephalitis. The use of cholesterol-added GM1 antigens increased anti-GM1 activity in 11 out of 23 anti-GM1-positive patients and resulted in six out of 100 anti-GM1-negative patients becoming anti-GM1-positive. Enhancement of anti-GM1 activity by cholesterol addition was significantly associated with antecedent gastrointestinal infection. The use of cholesterol-added glycolipid antigens can increase the detection rate of anti-glycolipid antibodies and accurately evaluate the anti-glycolipid antibody activity in vivo. |
| DOI | 10.1016/j.jneuroim.2021.577580 |
| PMID | 33933819 |