イチキ　ヨシノブ   ICHIKI Yoshinobu   市来　嘉伸    所属   埼玉医科大学  医学部 国際医療センター　呼吸器外科    職種   専任講師
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読なし
表題	Expression of KK-LC-1, a cancer/testis antigen, at non-tumour sites of the stomach carrying a tumour.
掲載誌名	正式名：Scientific reports
巻・号・頁	8(1),6131-6131頁
著者・共著者	Takashi Fukuyama,Nobue Futawatari,Rui Yamamura,Taiga Yamazaki,Yoshinobu Ichiki,Akira Ema,Hideki Ushiku,Yatsushi Nishi,Yoshihito Takahashi,Toshikazu Otsuka,Hitoshi Yamazaki,Wasaburo Koizumi,Kosei Yasumoto,Noritada Kobayashi
発行年月	2018/04
概要	Kita-Kyushu lung cancer antigen-1 (KK-LC-1) is a cancer/testis antigen (CTA) and predominant target for cancer immunotherapy. Our previous study indicated that KK-LC-1 was expressed in 82% of gastric cancers, and also in 79% of early stage of gastric cancers, with a correlation to Helicobacter pylori (H. pylori) infection. In addition, we found that KK-LC-1 was occasionally expressed at non-tumour sites of stomachs carrying tumours. Here, we investigated the characteristics of KK-LC-1 expression atnon-tumour sites and the clinical utility of these phenomena. The gene expression of KK-LC-1 was detected at the non-tumour sites including pyloric glands. The most detectable corpus/gland subset had a KK-LC-1 expression rate of 77% in the pyloric gland of the lower corpus where H. pylori preferentially exists. KK-LC-1 expression rates were 67% or 32% with or without intestinal metaplasia, which also induced by H. pylori, respectively. Consequently, KK-LC-1 would be detected at the pre-cancerous condition of the stomach, and may be a useful marker to predict gastric cancer.
DOI	10.1038/s41598-018-24514-9
PMID	29666402