イチキ　ヨシノブ   ICHIKI Yoshinobu   市来　嘉伸    所属   埼玉医科大学  医学部 国際医療センター　呼吸器外科    職種   専任講師
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読なし
表題	Effect of erlotinib plus bevacizumab on brain metastases in patients with non-small cell lung cancer.
掲載誌名	正式名：Annals of translational medicine
巻・号・頁	6(20),401-401頁
著者・共著者	Yasuhiro Chikaishi,Masatoshi Kanayama,Akihiro Taira,Yusuke Nabe,Shinji Shinohara,Taiji Kuwata,Masaru Takenaka,Soichi Oka,Ayako Hirai,Koji Kuroda,Naoko Imanishi,Yoshinobu Ichiki,Fumihiro Tanaka
発行年月	2018/10
概要	Background: The standard therapy for brain metastasis (BM) in non-small cell lung cancer (NSCLC) is radiation therapy (RT), although it is associated with complications such as leukoencephalopathy. In the current report, we retrospectively review data from eight patients who had NSCLC and harbored epidermal growth factor receptor (EGFR) mutations, and who were received erlotinib plus bevacizumab (E+B) as first-line therapy for BM. Methods: Patients were given E+B as first therapy for BM until August 2017 at our institution. Patients receiving local therapy for BM, such as surgery or radiotherapy, were excluded. Patients were administered erlotinib orally (once daily at 150 mg/body) plus bevacizumab by intravenous infusion (15 mg/kg on day 1 of a 21- or 28-day cycle). Results: Eight NSCLC patients who were diagnosed with BM received E+B, including 2 men and 6 women with a median age of 65 years (range, 46-84 years). Four patients had an L858R EGFR mutation, while the other four had an exon 19 deletion. Seven patients had a partial response to E+B treatment, and one had a complete response. The 2-year survival rate was 62.5%. Three patients who were pre-treated with gefitinib had an
DOI	10.21037/atm.2018.09.33
PMID	30498728