イチキ　ヨシノブ   ICHIKI Yoshinobu   市来　嘉伸    所属   埼玉医科大学  医学部 国際医療センター　呼吸器外科    職種   専任講師
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読なし
表題	Conversion therapy from N3 unresectable lung adenocarcinoma to radical surgery: a case report.
掲載誌名	正式名：Annals of translational medicine
巻・号・頁	7(20),590-590頁
著者・共著者	Huali Hu,Shuai Zou,Ruofu Xu,Yoshinobu Ichiki,Dirk De Ruysscher,Fenglei Yu,Aihui Liao
発行年月	2019/10
概要	Patients with N3 non-small cell lung cancer (NSCLC) have unresectable tumors. Although significant progress has been made in the past decades for such tumors, the average median survival time remains at 10 months. Equally dismal long-term survival rates were reported with the average 5-year-suvival rate at 9%. Here, we report on a case of a patient with locally advanced disease that was treated with conversion therapy using targeted anti-PD-1 immunotherapy with platinum-based chemotherapy. Following this therapeutic regimen, the tumor showed a reversion to pN0 from pN3 and the patient showed a progression free survival time of at least 33 months.
DOI	10.21037/atm.2019.09.113
PMID	31807571