ジュウジョウ　ケンタロウ   JUJO Kentaro   重城　健太郎    所属   埼玉医科大学  医学部 総合医療センター　心臓内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Contrasting roles of E2F2 and E2F3 in endothelial cell growth and ischemic angiogenesis
掲載誌名	正式名：JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY ISSNコード：00222828
出版社	ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
巻・号・頁	60,68-71頁
著者・共著者	Junlan Zhou,Min Cheng,Min Wu,Chan Boriboun,Kentaro Jujo,Shiyue Xu,Ting C. Zhao,Yao-Liang Tang,Raj Kishore,Gangjian Qin
発行年月	2013/07
概要	The growth of new blood vessels after ischemic injury requires endothelial cells (ECs) to divide and proliferate, and the E2F transcription factors are key regulators of the genes responsible for cell-cycle progression; however, the specific roles of individual E2Fs in ECs are largely unknown. To determine the roles of E2F2 and E2F3 in EC proliferation and the angiogenic response to ischemic injury, hind-limb ischemia was surgically induced in E2F2(-/-) mice, endothelial-specific E2F3-knockout (EndoE2F3(Delta/Delta)) mice, and their littermates with wild-type E2F2 and E2F3 expression. Two weeks later, Laser-Doppler perfusion measurements, capillary density, and endothelial proliferation were significantly greater in E2F2(-/-) mice and significantly lower in EndoE2F3(Delta/Delta) mice than in their littermates, and EndoE2F3(Delta/Delta) mice also developed toe and limb necrosis. The loss of E2F2 expression was associated with increases in the proliferation and G1/S-phase gene expression of isolated ECs, while the loss of E2F3 expression led to declines in these parameters. Thus E2F2 impairs, and endothelial E2F3 promotes, the angiogenic response to peripheral ischemic injury through
DOI	10.1016/j.yjmcc.2013.04.009