ジュウジョウ　ケンタロウ   JUJO Kentaro   重城　健太郎    所属   埼玉医科大学  医学部 総合医療センター　心臓内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Impact of left ventricular ejection function on blood pressure-lowering therapy in hypertensive patients with coronary artery disease
掲載誌名	正式名：JOURNAL OF HYPERTENSION ISSNコード：02636352
出版社	LIPPINCOTT WILLIAMS&WILKINS
巻・号・頁	34(5),1011-1018頁
著者・共著者	Noriko Kikuchi,Kentaro Jujo,Junichi Yamaguchi,Hiroshi Ogawa,Nobuhisa Hagiwara
発行年月	2016/05
概要	Objective:The prognosis of hypertensive patients with reduced left ventricular ejection fraction (LVEF) is poorer than that with normal LVEF. The influence of LVEF on blood pressure (BP)-lowering therapy remains unclear. The aim of this study was to clarify the impact of LVEFon clinical outcomes of BP-lowering therapy in hypertensive patients with coronary artery disease (CAD).Methods:This study was a post hoc analysis from Heart Institute of Japan Candesartan Randomized Trial for Evaluation in Coronary Heart Disease trial, a total of 2049 hypertensive patients with CAD were included. We analyzed 1849 patients with available LVEF data on enrollment. They were divided into three groups based on LVEF; reduced (<45%, n=386), intermediate (45-55%, n=524), and preserved (>55%, n=999). The achieved SBP' was defined as the mean value of SBP in patients who did not experience major adverse cardiac events (MACE) and the mean value of SBP prior to MACE in those who experienced MACE.Results:During a median follow-up period of 4.2 years, MACE rates were 30.6, 27.6, and 24.0% in the reduced, intermediate, and preserved LVEF groups, respectively. A J-shaped association between achieved SB
DOI	10.1097/HJH.0000000000000874