ジュウジョウ　ケンタロウ   JUJO Kentaro   重城　健太郎    所属   埼玉医科大学  医学部 総合医療センター　心臓内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Cancer antigen-125 plasma level as a biomarker of new-onset atrial fibrillation in postmenopausal women
掲載誌名	正式名：HEART ISSNコード：13556037
出版社	BMJ PUBLISHING GROUP
巻・号・頁	103(17),1368-1373頁
著者・共著者	Haruki Sekiguchi,Ken Shimamoto,Mayu Takano,Makiko Kimura,Yufuko Takahashi,Fujio Tatsumi,Eri Watanabe,Kentaro Jujo,Naoko Ishizuka,Masatoshi Kawana,Nobuhisa Hagiwara
発行年月	2017/09
概要	Objective Plasma cancer antigen (CA)-125 is a tumour marker recently shown to be associated with systolic heart failure and new-onset atrial fibrillation (AF) after myocardial infarction. However, no reports have described the relationship between CA-125 and new-onset AF in healthy postmenopausal women. The aim of the present study was to evaluate the relationship between CA-125 and new-onset AF in postmenopausal women.Methods Between 2005 and 2015, 2086 women, including 1012 postmenopausal women, visited our hospital for annual health check-ups. We excluded patients with systolic dysfunction, chronic inflammatory disease, chronic obstructive pulmonary disease, histories of AF or neoplastic diseases. A total of 746 postmenopausal women underwent thorough physical examinations, including those for biomarkers such as brain natriuretic peptide, high-sensitivity C-reactive protein (hs-CRP) and CA-125.Results During the 10-year observation period, AF was documented in 31 participants (4.2%). The mean age of participants developing AF (75 +/- 6 years) was higher than that of those without AF (68 +/- 8 years). Participants developing AF showed significantly higher CA-125 (11.4 +/- 6.3 U
DOI	10.1136/heartjnl-2016-310272