ジュウジョウ　ケンタロウ   JUJO Kentaro   重城　健太郎    所属   埼玉医科大学  医学部 総合医療センター　心臓内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Pilot Cohort Study Assessing the Efficacy of Endovascular Revascularization in the Restoration of Peripheral Sensory Disturbance in Patients With Critical Limb Ischemia
掲載誌名	正式名：CIRCULATION JOURNAL ISSNコード：13469843
出版社	JAPANESE CIRCULATION SOC
巻・号・頁	81(12),1919-+頁
著者・共著者	Kentaro Jujo,Katsumi Saito,Issei Ishida,Yuho Furuki,Eiji Shibahashi,Kensuke Shimazaki,Haruki Sekiguchi,Yuichiro Minami,Junichi Yamaguchi,Hiroshi Ogawa,Nobuhisa Hagiwara
発行年月	2017/12
概要	Background: Sensory disturbance (SD) is a common consequence of peripheral nerve damage associated with diabetes and severe ischemia. Progression of SD places patients at high risk for lower extremity ulcers and amputations. SD has been thought to be progressive and irreversible, and possibly caused by microvascular dysfunction. The aim of this study was to determine whether endovascular revascularization (EVR) induces quantifiable changes in SD in chronic critical limb ischemia (CLI) patients with neuropathy.Methods and Results: In all, 36 legs from 28 chronic CLI patients who underwent elective EVR were prospectively enrolled in this study (64% with diabetes and 54% on maintenance hemodialysis). The current perception threshold (CPT), an established diagnostic parameter for SD, was measured before and 3 months after EVR. Of the target lesions, 11%, 47%, and 81% were in the aortoiliac, femoropopliteal, and below-the-knee arteries, respectively, and 58% were totally occluded. Overall CPT in the target foot had improved significantly 3 months after EVR (from 53 to 30 mu A; P=0.010); however, EVR did not change CPT in the non-target foot (from 44 to 33 mu A; P=0.33). Patients with i
DOI	10.1253/circj.CJ-17-0405