ジュウジョウ　ケンタロウ   JUJO Kentaro   重城　健太郎    所属   埼玉医科大学  医学部 総合医療センター　心臓内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Contrast-Induced Nephropathy and Oxygen Pretreatment in Patients With Impaired Renal Function
掲載誌名	正式名：Kidney International Reports ISSNコード：24680249
出版社	Elsevier Inc
巻・号・頁	3(1),65-72頁
著者・共著者	Haruki Sekiguchi,Yoichi Ajiro,Yoshie Uchida,Kentaro Jujo,Kazunori Iwade,Naohide Tanaka,Ken Shimamoto,Yukio Tsurumi,Masatoshi Kawana,Nobuhisa Hagiwara,Yokohama Medical Center Clinical Research Group
発行年月	2018
概要	Introduction: Contrast-induced nephropathy is a complication following coronary angiography and percutaneous coronary intervention. Because contrast-induced nephropathy is a predictor of long-term mortality in patients with ischemic heart disease undergoing percutaneous coronary intervention, preventive strategies are required. We assessed the effects of periprocedural oxygenation on contrast-induced nephropathy among patients with pre-existing renal dysfunction. Methods: A total of 200 consecutive patients with impaired renal function (estimated glomerular filtration&lt 60 ml/min per 1.73 m2) undergoing elective cardiovascular angiography were randomly assigned to an oxygenation treatment (n = 100) or control group (n = 100). In oxygenation treatment, pure oxygen (2 L/min) was administered for 10 minutes before exposure to contrast medium. The primary endpoint was the incidence of contrast-induced nephropathy, defined as a ≥ 25% increase in serum creatinine levels from baseline within 48 hours of exposure. Results: In the oxygenation treatment group, partial pressureof arterial oxygen was higher (135 ± 25 mm Hg vs. 84 ± 10 mm Hg, P&lt 0.001) contrast-induced nephropathy
DOI	10.1016/j.ekir.2017.08.002