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ジュウジョウ ケンタロウ
JUJO Kentaro
重城 健太郎 所属 埼玉医科大学 医学部 総合医療センター 心臓内科 職種 教授 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Correction to: Good response to tolvaptan shortens hospitalization in patients with congestive heart failure (Heart and Vessels, (2018), 33, 4, (374-383), 10.1007/s00380-017-1072-6) |
| 掲載誌名 | 正式名：Heart and Vessels ISSNコード：09108327 |
| 出版社 | Springer Tokyo |
| 巻・号・頁 | 33(4),374-383頁 |
| 著者・共著者 | Tomohito Kogure,Kentaro Jujo,Kazuyuki Hamada,Katsumi Saito,Nobuhisa Hagiwara |
| 発行年月 | 2018/04 |
| 概要 | Tolvaptan has been gradually spread to use as a potent diuretic for congestive heart failure in the limited country. However, the response to this aquaretic drug still is unpredictable. A total of 92 patients urgently hospitalized due to congestive heart failure and treated with tolvaptan in addition to standard treatment was retrospectively analyzed. Responder of tolvaptan treatment wasdefined as a patient with peak negative fluid balance greater than 500 mL/day, and clinical profiles were compared between 76 responders and 16 non-responders. Responders started to increase daily urine volume (UV) from Day 1 through Day 3. In contrast, non-responders showed no significant increase in daily UV from the baseline up to Day 5. Time between admission and tolvaptan administration was shorter in responders, even without statistical significance (3.3 vs. 4.6 days, p = 0.053). Multivariate analysis revealed that blood urea nitrogen (BUN) [cutoff: 34 mg/dL, odds ratio (OR) 9.0, 95% confidence interval (CI) 1.42–57.3, p < 0.01]and plasma renin activity (PRA) (cutoff: 4.7 ng/mL/h, OR 6.1, 95% CI 1.01–36.4, p < 0.01) at baseline were independent predictors for tolvaptan re |
| DOI | 10.1007/s00380-017-1072-6 |