ジュウジョウ　ケンタロウ   JUJO Kentaro   重城　健太郎    所属   埼玉医科大学  医学部 総合医療センター　心臓内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読なし
表題	Short-term effects of low-dose tolvaptan in acute decompensated heart failure patients with severe aortic stenosis: The LOHAS registry.
掲載誌名	正式名：International journal of cardiology
巻・号・頁	305,82-86頁
著者・共著者	Yusuke Watanabe,Yugo Nara,Hirofumi Hioki,Hideyuki Kawashima,Akihisa Kataoka,Makoto Nakashima,Yosuke Nishihata,Kentaro Hayashida,Masanori Yamamoto,Jun Tanaka,Kazuki Mizutani,Kentaro Jujo,Gaku Nakazawa,Masaki Izumo,Ken Kozuma
発行年月	2020/04
概要	BACKGROUND: Tolvaptan exerts potent diuretic effects in heart failure patients without hemodynamic instability. Nonetheless, its clinical efficacy for acute decompensated heart failure (ADHF) due to severe aortic stenosis (AS) remains unclear. This study aimed to evaluate the short-term effects of tolvaptan in ADHF patients with severe AS. METHODS: The LOw-Dose Tolvaptan (7.5 mg) in Decompensated Heart Failure Patients with Severe Aortic Stenosis (LOHAS) registry is a multicenter (7 centers) prospective registry that assessed the short-term effects of tolvaptan in subjects hospitalized for ADHF with severe AS. A total of 59 subjects were enrolled between September 2014 and December 2017. The primary endpoints were changes in body weight and fluid balance measured daily from baseline up to 4 days. RESULTS: The median [interquartile range]patient age and aortic valve area were 85.0 [81.0-89.0]years and 0.58 [0.42-0.74]cm2, respectively. Body weight continuously decreased, and fluid balance was maintained from baseline to day 4 (p < 0.001, p = 0.194, respectively). Median serum B-type natriuretic peptide concentration significantly decreased from 910.5 to 740.0 pg/mL by day
DOI	10.1016/j.ijcard.2020.02.017
PMID	32059993