ジュウジョウ　ケンタロウ   JUJO Kentaro   重城　健太郎    所属   埼玉医科大学  医学部 総合医療センター　心臓内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読なし
表題	Prevalence and prognostic impact of the coexistence of multiple frailty domains in elderly patients with heart failure: the FRAGILE-HF cohort study.
掲載誌名	正式名：European journal of heart failure
巻・号・頁	22(11),2112-2119頁
著者・共著者	Yuya Matsue,Kentaro Kamiya,Hiroshi Saito,Kazuya Saito,Yuki Ogasahara,Emi Maekawa,Masaaki Konishi,Takeshi Kitai,Kentaro Iwata,Kentaro Jujo,Hiroshi Wada,Takatoshi Kasai,Hirofumi Nagamatsu,Tetsuya Ozawa,Katsuya Izawa,Shuhei Yamamoto,Naoki Aizawa,Ryusuke Yonezawa,Kazuhiro Oka,Shin-Ichi Momomura,Nobuyuki Kagiyama
発行年月	2020/11
概要	AIMS: To describe the prevalence, overlap, and prognostic implications of physical and social frailties and cognitive dysfunction in hospitalized elderly patients with heart failure. METHODS AND RESULTS: The FRAGILE-HF study was a prospective multicentre cohort study enrolling consecutive hospitalized patients with heart failure aged ≥65 years. The study objectives were to examine the prevalence, overlap, and prognostic implications of the coexistence of multiple frailty domains. Physical frailty, social frailty, and cognitive dysfunction were evaluated by the Fried phenotype model, Makizako's 5 items, and Mini-Cog, respectively. The primary study outcome was the combined endpoint of heart failure rehospitalization and all-cause death within 1 year. Among 1180 enrolled hospitalized patients (median age, 81 years; 57.4% male), physical frailty, social frailty, and cognitive dysfunction were identified in 56.1%, 66.4%, and 37.1% of the patients, respectively. The number of identified frailty domains was 0, 1, 2, and 3 in 13.5%, 31.4%, 36.9%, and 18.2% of the patients, respectively. During follow-up, the combined endpoint occurred in 383 patients. Adjusted hazard ratios for 1,
DOI	10.1002/ejhf.1926
PMID	32500539