ジュウジョウ　ケンタロウ   JUJO Kentaro   重城　健太郎    所属   埼玉医科大学  医学部 総合医療センター　心臓内科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読なし
表題	Impact of sarcopenia on prognosis in patients with heart failure with reduced and preserved ejection fraction.
掲載誌名	正式名：European journal of preventive cardiology
著者・共著者	Masaaki Konishi,Nobuyuki Kagiyama,Kentaro Kamiya,Hiroshi Saito,Kazuya Saito,Yuki Ogasahara,Emi Maekawa,Toshihiro Misumi,Takeshi Kitai,Kentaro Iwata,Kentaro Jujo,Hiroshi Wada,Takatoshi Kasai,Hirofumi Nagamatsu,Tetsuya Ozawa,Katsuya Izawa,Shuhei Yamamoto,Naoki Aizawa,Akihiro Makino,Kazuhiro Oka,Shin-Ichi Momomura,Yuya Matsue
発行年月	2020/11
概要	AIMS: Sarcopenia, one of the extracardiac factors for reduced functional capacity and poor outcome in heart failure (HF), may act differently between HF with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF). We sought to investigate the impact of sarcopenia on mortality in HFpEF and HFrEF. METHODS AND RESULTS: We performed a post hoc analysis of a multicentre prospective cohort study, including 942 consecutive older (age ≥65 years) hospitalized patients: 475 with HFpEF (ejection fraction ≥45%, age 81 ± 7 years, 48.8% men) and 467 with HFrEF (ejection fraction<45%, age 78 ± 8 years, 68.1% men). Sarcopenia was diagnosed according to the international criteria incorporating muscle strength (handgrip strength), physical performance (gait speed), and skeletal muscle mass (appendicular skeletal mass). The HFpEF group consisted of fewer patients with low appendicular skeletal muscle mass index measured using bioelectrical impedance analysis [<7.0 kg/m2 (men) and<5.7 (women); 22.1% vs. 31.0%, P = 0.003], and more patients with low handgrip strength [<26 kg (men) and<18 (women); 67.8% vs. 55.5%, P < 0.001], and slow gait sp
DOI	10.1093/eurjpc/zwaa117
PMID	33624112