セキ　マサフミ   SEK Masafumi   関　雅文    所属   埼玉医科大学  医学部 国際医療センター　感染症科・感染制御科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読なし
表題	Efficacy of SPK-843, a novel polyene antifungal, in comparison with amphotericin B, liposomal amphotericin B, and micafungin against murine pulmonary aspergillosis.
掲載誌名	正式名：Antimicrobial agents and chemotherapy
巻・号・頁	52(5),1868-70頁
著者・共著者	Hiroshi Kakeya,Yoshitsugu Miyazaki,Hisato Senda,Tsutomu Kobayashi,Masafumi Seki,Koichi Izumikawa,Kazunori Yanagihara,Yoshihiro Yamamoto,Takayoshi Tashiro,Shigeru Kohno
発行年月	2008/05
概要	SPK-843, a new polyene antifungal, exhibited dose-dependent efficacy on murine pulmonary aspergillosis models. SPK-843 doses of higher than 1.0 mg/kg of body weight exhibited no renal toxicities and a tendency toward better survival prolongation than the estimated maximum tolerated doses of amphotericin B (Fungizone) (1.0 mg/kg) and liposomal amphotericin B (AmBisome) (8.0 mg/kg).
DOI	10.1128/AAC.01369-07
PMID	18299412