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セキ マサフミ
SEK Masafumi
関 雅文 所属 埼玉医科大学 医学部 国際医療センター 感染症科・感染制御科 職種 教授 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読なし |
| 表題 | Efficacy of SPK-843, a novel polyene antifungal, in a murine model of systemic cryptococcosis. |
| 掲載誌名 | 正式名：Antimicrobial agents and chemotherapy |
| 巻・号・頁 | 52(5),1871-2頁 |
| 著者・共著者 | Hiroshi Kakeya,Yoshitsugu Miyazaki,Hisato Senda,Tsutomu Kobayashi,Masafumi Seki,Koichi Izumikawa,Yoshihiro Yamamoto,Kazunori Yanagihara,Takayoshi Tashiro,Shigeru Kohno |
| 発行年月 | 2008/05 |
| 概要 | SPK-843, a new polyene antifungal, possessed efficacy in a murine model of systemic infection caused by Cryptococcus neoformans. The administration of 4.0 mg/kg SPK-843 led to better survival prolongation and fungal reduction than those observed with the administration of 0.7 mg/kg amphotericin B and 80 mg/kg fluconazole (P<0.001), without histopathological renal changes. |
| DOI | 10.1128/AAC.01370-07 |
| PMID | 18299408 |