セキ　マサフミ   SEK Masafumi   関　雅文    所属   埼玉医科大学  医学部 国際医療センター　感染症科・感染制御科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読なし
表題	Reversible visual disturbance due to cryptococcal uveitis in a non-HIV individual.
掲載誌名	正式名：Medical mycology
巻・号・頁	46(4),367-70頁
著者・共著者	Shigeki Nakamura,Koichi Izumikawa,Masafumi Seki,Kyoko Fujimoto,Kazuaki Mishima,Hiroshi Kakeya,Yoshihiro Yamamoto,Katsunori Yanagihara,Yohei Mizuta,Takashi Kitaoka,Shigeru Kohno
発行年月	2008/06
概要	A 52-year-old man without underlying diseases visited a local hospital with symptoms of memory deficit and mild headache. Radiological examination of the brain with computed tomography (CT) revealed hydrocephalus. Etiology was not revealed by cerebrospinal fluid (CSF) analysis and a ventricular-atrial (V-A) shunt was installed. The patient had congestion and dacryorrhea of the right eye and uveitis was diagnosed three months after placement of the V-A shunt. The serum cryptococcal antigen (CrAg) tested positive at atitration of 64 times. Additionally, samples of the right eye anterior chamber aqueous humor (ACAH), cerebrospinal fluid (CSF) and prostate fluid were positive for Cryptococcus antigen at a titration of 128 times. In addition, Cryptococcus neoformans var. grubii was isolated from the peripheral blood, CSF and ACAH, resulting in a diagnosis of disseminated cryptococcosis. Fluconazole (FLCZ) at 800 mg/day was administered for the first two days, followed by a 400 mg/day maintenance dose. After six months of treatment, his visual power recovered. This is a rare case of disseminated cryptococcosis involving uveitis, which was successfully treated by FLCZ. Disseminated crypt
DOI	10.1080/13693780701885461
PMID	18415845