セキ　マサフミ   SEK Masafumi   関　雅文    所属   埼玉医科大学  医学部 国際医療センター　感染症科・感染制御科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読なし
表題	Lung fibrosis 10 years after cessation of bleomycin therapy.
掲載誌名	正式名：The Tohoku journal of experimental medicine ISSNコード：00408727
巻・号・頁	216(1),77-80頁
著者・共著者	Masato Tashiro,Koichi Izumikawa,Daisuke Yoshioka,Shigeki Nakamura,Shintaro Kurihara,Noriho Sakamoto,Masafumi Seki,Hiroshi Kakeya,Yoshihiro Yamamoto,Katunori Yanagihara,Hiroshi Mukae,Tomayoshi Hayashi,Kiyoyasu Fukushima,Takayoshi Tashiro,Shigeru Kohno
発行年月	2008/09
概要	Bleomycin (BLM) is a chemotherapeutic agent used for the treatment of several types of malignancy, including germ cell tumors, lymphoma, and certain types of squamous-cell carcinoma. The common adverse effect of BLM is interstitial pneumonitis, followed by pulmonary fibrosis. BLM-induced pneumonitis occurs in up to 46% of patients treated with BLM-containing chemotherapy and lung toxicity usually appears during treatment. Here we describe a patient with lung fibrosis, who presented with slow progressive breathlessness and pneumothorax more than 10 years after cessation of BLM therapy. A 15 year-old girl presented with abnormal shadows on chest X-ray. The patient had a yolk sac carcinoma in the sacral region at 1 year of age and obtained complete remission after being treated with tumor resection, radiation, and several anti-cancer drugs including BLM. There were no abnormal findings in chest X-ray until she reached 3 years of age, when she had developed respiratory distress that worsened with age. The patient had experienced an episode of pneumothorax at 13 years of age. Chest CT at the time revealed interstitial reticular opacities. Radiological findings and pathological examinati
DOI	10.1620/tjem.216.77
NAID	10021951715
PMID	18719341