セキ　マサフミ   SEK Masafumi   関　雅文    所属   埼玉医科大学  医学部 国際医療センター　感染症科・感染制御科    職種   教授
論文種別	学術雑誌(原著)
言語種別	日本語
査読の有無	査読あり
表題	[Efficacy of sivelestat for acute lung injury due to severe bacterial pneumonia with systemic inflammatory response syndrome].
掲載誌名	正式名：Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society ISSNコード：13433490
巻・号・頁	46(10),793-7頁
著者・共著者	Shigeki Nakamura,Katsunori Yanagihara,Koichi Izumikawa,Masafumi Seki,Hiroshi Kakeya,Yoshihiro Yamamoto,Hiroshi Mukae,Takayoshi Tashiro,Shigeru Kohno
発行年月	2008/10
概要	OBJECTIVE: Neutrophil elastase is believed to play an important role in acute lung injury (ALI). Sivelestat is a small molecular weight neutrophil elastase inhibitor. Although some authors reported its efficacy in ALI, it is unclear whether sivelestat has good effects in ALI, especially in cases due to severe bacterial pneumonia. The purpose of this study is to investigate the effect of sivelestat to ALI due to severe bacterial pneumonia. METHODS: We performed a retrospective study of 28 patients who were admitted for severe bacterial pneumonia (pneumonia severity index; PSI class V). We investigated the patients' background, pneumonia severity score, the days from diagnosis of systemic inflammatory response syndrome (SIRS) to sivelestat administration, P/F ratio, SIRS score, and compared two groups: those who survived and those who died. RESULTS: There were no significant background differences between the two groups. In pneumonia severity score, chest X-ray film score was higher in the group of fatalities than in the survival group. In the survival cases, sivelestat had been administered earlier than in the cases that died. In the survival cases, improvement in P/F ratio, body te
PMID	19044028