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セキ マサフミ
SEK Masafumi
関 雅文 所属 埼玉医科大学 医学部 国際医療センター 感染症科・感染制御科 職種 教授 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読なし |
| 表題 | In Vitro Activity of Garenoxacin against Streptococcus pneumoniae Mutants with Characterized Resistance Mechanisms |
| 掲載誌名 | 正式名：ANTIMICROBIAL AGENTS AND CHEMOTHERAPY ISSNコード：00664804 |
| 出版社 | AMER SOC MICROBIOLOGY |
| 巻・号・頁 | 53(8),3572-3575頁 |
| 著者・共著者 | Kazuko Yamamoto,Katsunori Yanagihara,Kazuyuki Sugahara,Yoshifumi Imamura,Masafumi Seki,Koichi Izumikawa,Hiroshi Kakeya,Yoshihiro Yamamoto,Yoichi Hirakata,Shimeru Kamihira,Shigeru Kohno |
| 発行年月 | 2009/08 |
| 概要 | We evaluated the potency of garenoxacin in selecting resistant Streptococcus pneumoniae mutants by determining its mutant prevention concentration, using strains with and without topoisomerase gene mutations, and compared its potency to that of other quinolones. Garenoxacin had a significantly greater potency against pneumococci, including strains containing topoisomerase mutations. Genetic analysis of the S. pneumoniae mutants created by garenoxacin revealed that the gyrA gene was a primary target of garenoxacin. |
| DOI | 10.1128/AAC.00176-09 |
| PMID | 19451290 |