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セキ マサフミ
SEK Masafumi
関 雅文 所属 埼玉医科大学 医学部 国際医療センター 感染症科・感染制御科 職種 教授 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読なし |
| 表題 | In vivo efficacy of sitafloxacin in a new murine model of non-typeable Haemophilus influenzae pneumonia by sterile intratracheal tube. |
| 掲載誌名 | 正式名：International journal of antimicrobial agents |
| 巻・号・頁 | 34(3),210-4頁 |
| 著者・共著者 | Shigeki Nakamura,Katsunori Yanagihara,Nobuko Araki,Yoshitomo Morinaga,Koichi Izumikawa,Masafumi Seki,Hiroshi Kakeya,Yoshihiro Yamamoto,Shimeru Kamihira,Shigeru Kohno |
| 発行年月 | 2009/09 |
| 概要 | A novel murine model of non-typeable Haemophilus influenzae (NTHi) pneumonia was established. A plastic tube was inserted into the trachea 7 days before bacterial inoculation. Numbers of NTHi recovered from the lungs and trachea were determined for 7 days. Histologically, bronchioles and adjacent alveoli in the intubation group were filled with numerous inflammatory cells. The efficacy of sitafloxacin was compared with ciprofloxacin using the new murine pneumonia model. The data suggest that sitafloxacin displays equivalent efficacy to ciprofloxacin against H. influenzae pneumonia. This new murine NTHi pneumonia model appears useful not only for in vivo evaluation of antibiotics but also for analysis of the pathogenesis of H. influenzae pneumonia. |
| DOI | 10.1016/j.ijantimicag.2009.03.011 |
| PMID | 19394203 |