セキ　マサフミ   SEK Masafumi   関　雅文    所属   埼玉医科大学  医学部 国際医療センター　感染症科・感染制御科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読なし
表題	Efficacy of linezolid against Panton-Valentine leukocidin (PVL)-positive meticillin-resistant Staphylococcus aureus (MRSA) in a mouse model of haematogenous pulmonary infection
掲載誌名	正式名：INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS ISSNコード：09248579
出版社	ELSEVIER SCIENCE BV
巻・号・頁	34(5),477-481頁
著者・共著者	Katsunori Yanagihara,Rie Kihara,Nobuko Araki,Yoshitomo Morinaga,Masafumi Seki,Koichi Izumikawa,Hiroshi Kakeya,Yoshihiro Yamamoto,Yasuaki Yamada,Shigeru Kohno,Kazuhiro Tsukamoto,Shimeru Kamihira
発行年月	2009/11
概要	Many strains of community-acquired meticillin-resistant Staphylococcus aureus (MRSA) have a pore-forming leukotoxin, known as Panton-Valentine leukocidin (PVL), which can cause severe necrotising pneumonia. Linezolid (LZD) is a new antibacterial agent with potent antibacterial activity against MRSA. In this study, a mouse model of haematogenous pulmonary infection was used to compare the efficacies of LZD and vancomycin (VAN) against pulmonary infection caused by PVL-positive S. aureus. Following antibiotic administration for 3 days, the number of viable bacteria (mean +/- standard error of the mean) in the control, VAN and LZD groupswas 6.77 +/- 0.14, 5.29 +/- 0.27 and 4.25 +/- 0.33 log colony-forming units/lung, respectively. LZD significantly decreased the number of viable bacteria in the lungs compared with the control and VAN groups (P<0.05). The survival rate at Day 7 post-inoculation was higher in the LZD group (100%) than in the VAN group (50%) or the control group (0%). Histopathological examination and cytokine analysis also showed the beneficial efficacy of LZD compared with VAN. In conclusion, LZD significantly reduced bacterial numbers and inflammation in a mouse mod
DOI	10.1016/j.ijantimicag.2009.06.024
PMID	19665359