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セキ マサフミ
SEK Masafumi
関 雅文 所属 埼玉医科大学 医学部 国際医療センター 感染症科・感染制御科 職種 教授 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読なし |
| 表題 | Diffuse alveolar hemorrhage following itraconazole injection. |
| 掲載誌名 | 正式名：Internal medicine (Tokyo, Japan) ISSNコード：09182918 |
| 巻・号・頁 | 49(5),497-500頁 |
| 著者・共著者 | Koichi Izumikawa,Ken Nakano,Shintaro Kurihara,Yoshifumi Imamura,Kazuko Yamamoto,Taiga Miyazaki,Noriho Sakamoto,Masafumi Seki,Yuji Ishimatsu,Hiroshi Kakeya,Yoshihiro Yamamoto,Katsunori Yanagihara,Tomoshi Tsuchiya,Naoya Yamasaki,Tsutomu Tagawa,Hiroshi Mukae,Takeshi Nagayasu,Shigeru Kohno |
| 発行年月 | 2010 |
| 概要 | Diffuse alveolar hemorrhage (DAH) syndrome is potentially fatal. We encountered a nearly fatal case of DAH possibly due to intravenous itraconazole (ITCZ). A 53-year-old man with chronic pulmonary aspergillosis underwent pneumonectomy of the left lung 15 days prior to the onset of DAH, which was confirmed by bronchoalveloar lavage. The battery of diagnostic evaluations performed revealed no other positive etiological factor, leading to the diagnosis of DAH possibly induced by intravenous ITCZ with a positive drug lymphocyte stimulation test. The patient did not respond to pulse methylprednisolone therapy, but responded dramatically to direct hemoperfusion using a polymyxin B-immobilized fiber column (PMX) therapy. |
| DOI | 10.2169/internalmedicine.49.2735 |
| NAID | 130000251704 |
| PMID | 20190492 |