セキ　マサフミ   SEK Masafumi   関　雅文    所属   埼玉医科大学  医学部 国際医療センター　感染症科・感染制御科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読なし
表題	Roles of calcineurin and Crz1 in antifungal susceptibility and virulence of Candida glabrata.
掲載誌名	正式名：Antimicrobial agents and chemotherapy
巻・号・頁	54(4),1639-43頁
著者・共著者	Taiga Miyazaki,Shunsuke Yamauchi,Tatsuo Inamine,Yosuke Nagayoshi,Tomomi Saijo,Koichi Izumikawa,Masafumi Seki,Hiroshi Kakeya,Yoshihiro Yamamoto,Katsunori Yanagihara,Yoshitsugu Miyazaki,Shigeru Kohno
発行年月	2010/04
概要	A Candida glabrata calcineurin mutant exhibited increased susceptibility to both azole antifungal and cell wall-damaging agents and was also attenuated in virulence. Although a mutant lacking the downstream transcription factor Crz1 displayed a cell wall-associated phenotype intermediateto that of the calcineurin mutant and was modestly attenuated in virulence, it did not show increased azole susceptibility. These results suggest that calcineurin regulates both Crz1-dependent and -independent pathways depending on the type of stress.
DOI	10.1128/AAC.01364-09
PMID	20100876