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セキ マサフミ
SEK Masafumi
関 雅文 所属 埼玉医科大学 医学部 国際医療センター 感染症科・感染制御科 職種 教授 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | In vivo efficacy of sivelestat in combination with pazufloxacin against Legionella pneumonia. |
| 掲載誌名 | 正式名：Experimental lung research ISSNコード：01902148 |
| 巻・号・頁 | 36(8),484-90頁 |
| 著者・共著者 | Yoshitomo Morinaga,Katsunori Yanagihara,Nobuko Araki,Koichi Yamada,Masafumi Seki,Koichi Izumikawa,Hiroshi Kakeya,Yoshihiro Yamamoto,Yasuaki Yamada,Shigeru Kohno,Shimeru Kamihira |
| 発行年月 | 2010/10 |
| 概要 | It is important to regulate excessive inflammation when patients with severe infectious disease are treated. Sivelestat sodium hydrate (sivelestat), a neutrophil elastase inhibitor, is used in the treatment of lung injury but its effect on bacterial pneumonia is unknown. The authors examined the efficacy of sivelestat in combination with a fluoroquinolone in a Legionella pneumophila pneumonia mouse model. The combination therapy did not show a significant survival improvement compared to the treatment with fluoroquinolone alone, but reduced bacteria number and inflammatory cells in the early phase. The combination therapy can contribute to treatment of L. pneumophila pneumonia with protecting lungs. |
| DOI | 10.3109/01902141003728874 |
| NAID | 120003367667 |
| PMID | 20939755 |