セキ　マサフミ   SEK Masafumi   関　雅文    所属   埼玉医科大学  医学部 国際医療センター　感染症科・感染制御科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Functional characterization of the regulators of calcineurin in Candida glabrata.
掲載誌名	正式名：FEMS yeast research ISSNコード：15671356
巻・号・頁	11(8),621-30頁
著者・共著者	Taiga Miyazaki,Koichi Izumikawa,Yohsuke Nagayoshi,Tomomi Saijo,Shunsuke Yamauchi,Yoshitomo Morinaga,Masafumi Seki,Hiroshi Kakeya,Yoshihiro Yamamoto,Katsunori Yanagihara,Yoshitsugu Miyazaki,Shigeru Kohno
発行年月	2011/12
概要	The serine-threonine-specific protein phosphatase calcineurin is a key mediator of various stress responses in fungi. Herein, we characterized functions of the endogenous regulators of calcineurin (RCNs), Rcn1 and Rcn2, in the pathogenic fungus Candida glabrata. Rcn1 exerted both inhibitory and stimulatory effects on calcineurin signaling, but Rcn2 displayed only inhibitory activity. Phenotypic analyses of C. glabrata strains lacking either RCNs, calcineurin, or both revealed that calcineurin requires Rcn1, but not Rcn2, for antifungal tolerance in C. glabrata.
DOI	10.1111/j.1567-1364.2011.00751.x
NAID	120003751871
PMID	22093746