セキ　マサフミ   SEK Masafumi   関　雅文    所属   埼玉医科大学  医学部 国際医療センター　感染症科・感染制御科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Nosocomial outbreak of multidrug-resistant Pseudomonas aeruginosa caused by damaged transesophageal echocardiogram probe used in cardiovascular surgical operations.
掲載誌名	正式名：Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy ISSNコード：14377780
出版社	Japanese Society for Cancer Chemotherapy
巻・号・頁	19(4),677-81頁
著者・共著者	Masafumi Seki,Hisako Machida,Yoshiaki Yamagishi,Hisao Yoshida,Kazunori Tomono
発行年月	2013/08
概要	Multidrug-resistant Pseudomonas aeruginosa (MDRP) is a major problem among hospital-acquired infections. We had a one-month outbreak of this strain at a university hospital in Osaka, Japan, from May to June 2004. To determine the cause of the outbreak, we collected and analyzed epidemiological information about the patients from whom MDRP was isolated, and performed microbiological investigations. MDRP was detected in respiratory specimens from eight patients in the intensive care unit. One of these patients developed severe lethal pneumonia accompanied by septicemia, and two contracted less severe non-lethal pneumonia. All the MDRP patients had been monitored with a contaminated transesophageal echocardiography (TOE) probe during their cardiac surgery. The TOE probe proved to have a defect 5 mm in diameter at the surface near the transducer, and the MDRP strain was traced to this defect. Pulsed-field gel electrophoresis showed that the strain isolated from the patients and from the TOE probe were genetically indistinguishable. After use of the damaged TOE probe was terminated,MDRP was not isolated from any patients who underwent cardiac surgery in the subsequent 8 years. In con
DOI	10.1007/s10156-012-0542-0
PMID	23292134