セキ　マサフミ   SEK Masafumi   関　雅文    所属   埼玉医科大学  医学部 国際医療センター　感染症科・感染制御科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Efficacy of combination therapy with oseltamivir phosphate and azithromycin for influenza: a multicenter, open-label, randomized study.
掲載誌名	正式名：PloS one ISSNコード：19326203
巻・号・頁	9(3),e91293頁
著者・共著者	Hiroshi Kakeya,Masafumi Seki,Koichi Izumikawa,Kosuke Kosai,Yoshitomo Morinaga,Shintaro Kurihara,Shigeki Nakamura,Yoshifumi Imamura,Taiga Miyazaki,Misuzu Tsukamoto,Katsunori Yanagihara,Takayoshi Tashiro,Shigeru Kohno
発行年月	2014
概要	BACKGROUND: Macrolides have antibiotic and immunomodulatory activities, which may have a favorable effect on the clinical outcome of patients with infections, including influenza. This study aimed to evaluate the effects of combination therapy with an anti-influenza agent, oseltamivir, and a single-dose formulation of azithromycin (AZM), which has been used for influenza-related secondary pneumonia, on influenza patients. The primary endpoint was a change in the expression levels of inflammatory cytokines. Secondary endpoints were the time required for resolution of influenza-related symptoms, incidence of complications, and adverse reactions. METHODS: Patients with seasonal influenza were enrolled in this multicenter, open-label, randomized study. Patients were stratified according to the presence of a high risk factor and were randomized to receive combination therapy with oseltamivir plus an extended-release formulation of AZM (combo-group) or oseltamivir monotherapy (mono-group). RESULTS: We enrolled 107 patients and randomized them into the mono-group (56 patients) or the combo-group (51 patients). All patients were diagnosed with influenza A infection, and none of the patient
DOI	10.1371/journal.pone.0091293
PMID	24632748