セキ　マサフミ   SEK Masafumi   関　雅文    所属   埼玉医科大学  医学部 国際医療センター　感染症科・感染制御科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	In vitro activity of various antibiotics against clinical strains of Legionella species isolated in Japan
掲載誌名	正式名：Journal of Infection and Chemotherapy ISSNコード：1341321X
出版社	Elsevier B.V.
巻・号・頁	24(5),325-329頁
著者・共著者	Naoyuki Miyashita,Intetsu Kobayashi,Futoshi Higa,Yosuke Aoki,Toshiaki Kikuchi,Masafumi Seki,Kazuhiro Tateda,Nobuko Maki,Kazuhiro Uchino,Kazuhiko Ogasawara,Satoe Kurachi,Tatsuya Ishikawa,Yoshito Ishimura,Izumo Kanesaka,Hiroshi Kiyota,Akira Watanabe
発行年月	2018/05
概要	© 2018 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases The activities of various antibiotics against 58 clinical isolates of Legionella species were evaluated using two methods, extracellular activity (minimum inhibitory concentration [MIC]) and intracellular activity. Susceptibility testing was performed using BSYEα agar. The minimum extracellular concentration inhibiting intracellular multiplication (MIEC) was determined using a human monocyte-derived cell line, THP-1. The most potent drugs in terms of MICs against clinical isolates were levofloxacin, garenoxacin, and rifampicin with MIC90 values of 0.015 μg/ml. The activities of ciprofloxacin, pazufloxacin, moxifloxacin, clarithromycin, and azithromycin were slightly higher than those of levofloxacin, garenoxacin, and rifampicin with an MIC90 of 0.03–0.06 μg/ml. Minocycline showed the highest activity, with an MIC90 of 1 μg/ml. No resistance against the antibiotics tested was detected. No difference was detected in the MIC distributions of the antibiotics tested between L. pneumophila serogroup 1 and L. pneumophila non-serogroup 1. The MIECs of ciprofloxacin, pazufloxacin, levofloxaci
DOI	10.1016/j.jiac.2018.01.018
PMID	29459000