セキ　マサフミ   SEK Masafumi   関　雅文    所属   埼玉医科大学  医学部 国際医療センター　感染症科・感染制御科    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Clinical manifestations of adult patients requiring influenza-associated hospitalization: A prospective multicenter cohort study in Japan via internet surveillance.
掲載誌名	正式名：Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy ISSNコード：1341321X
巻・号・頁	27(3),480-485頁
著者・共著者	Tadashi Ishida,Masafumi Seki,Kazunori Oishi,Kazuhiro Tateda,Jiro Fujita,Jun-Ichi Kadota,Akihiko Kawana,Koichi Izumikawa,Toshiaki Kikuchi,Norio Ohmagari,Mitsuhiro Yamada,Takaya Maruyama,Takahiro Takazono,Makoto Miki,Yoshitsugu Miyazaki,Yoshitaka Yamazaki,Hiroshi Kakeya,Kenji Ogawa,Hideaki Nagai,Akira Watanabe
発行年月	2021/03
概要	INTRODUCTION: Influenza remains a clinically heavy burden worldwide. The objective of this study was to clarify clinical manifestations of severely ill patients infected with influenza. METHODS: The clinical data for patients who were severely ill with influenza, and required hospitalization were gathered and analyzed between November 2014 and August 2019 (5 influenza seasons) using an internet-surveillance system. RESULTS: A total of 924 patients were enrolled and analyzed. The median age was 78 years (IQR, 67-84), and the patients in the 2015-2016 season were significantly younger than those in other seasons. Pneumonia was the most common disease indicated as a cause for hospitalization, followed by a poor general condition and exacerbation of underlying respiratory diseases. Antiviral drugs were administered in 97.0% of the patients with peramivir being the most-frequently use antiviral. In-hospital death was recorded for 44 patients (4.8%). Multivariate analysis indicated that nursing home resident (OR: 6.554) and obesity (OR: 24.343) were independent predictors of in-hospital mortality. CONCLUSIONS: Complications of influenza infection remain a heavy burden especially among th
DOI	10.1016/j.jiac.2020.10.021
PMID	33189538