オノ　コウジ   ONO Koji   小野　公嗣    所属   埼玉医科大学  保健医療学部 臨床検査学科    職種   准教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Potential pathophysiological role of d-amino acid oxidase in schizophrenia: immunohistochemical and in situ hybridization study of the expression in human and rat brain
掲載誌名	正式名：JOURNAL OF NEURAL TRANSMISSION ISSNコード：03009564
出版社	SPRINGER WIEN
巻・号・頁	116(10),1335-1347頁
著者・共著者	Koji Ono,Yuji Shishido,Hwan Ki Park,Tomoya Kawazoe,Sanae Iwana,Seong Pil Chung,Rabab M. Abou El-Magd,Kazuko Yorita,Mai Okano,Takeshi Watanabe,Nobuya Sano,Yoshimi Bando,Kunimasa Arima,Takashi Sakai,Kiyoshi Fukui
発行年月	2009/10
概要	d-Amino acid oxidase (DAO) is a peroxisomal flavoenzyme that catalyzes oxidative deamination of a wide range of d-amino acids. Among the possible substrates of DAO in vivo, d-serine is proposed to be a neuromodulator of the N-methyl-d-aspartate (NMDA) type glutamate receptor. The gene for DAO was reported to be associated with schizophrenia. Since DAO is expected to be one of the key enzymes in the regulation of NMDA neurotransmission, the modulation of the enzyme activity is expected to be therapeutical for neuronal disorders. In search of the pathophysiological role of DAO, we analyzed the distribution of DAO mRNA and protein in the rat and human brain. In rat, the distribution of DAO mRNA was newly detected in choroid plexus (CP) epithelial cells in addition to glial cells of pons, medulla oblongata, and especially Bergmann glia of cerebellum. Moreover, to investigate how DAO expression level is altered in schizophrenia, we performed immunohistochemistry in the human brain. In agreement with the results in the rat brain, the immunoreactivity for DAO was detected in glial cells of rhombencephalon and in CP. Furthermore, higher level of DAO expression was observed in schizophrenic
DOI	10.1007/s00702-009-0289-7