イノウエ　イクオ   INOUE Ikuo   井上　郁夫    所属   埼玉医科大学  医学部 教職員・学生健康推進センター    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
招待の有無	招待あり
表題	Effects of Pparγ1 deletion on late-stage murine embryogenesis and cells that undergo endocycle.
掲載誌名	正式名：Developmental biology 略　 称：Dev Biol
掲載区分	国外
巻・号・頁	1-10頁
著者・共著者	Nakano Takanari, Aochi Hidekazu, Hirasaki Masataka, Takenaka Yasuhiro, Fujita Koji, Tamura Masaru, Soma Hiroaki, Kamezawa Hajime, Koizumi Takahiro, Shibuya Hirotoshi, Inomata Reiko, Okuda Akihiko, Murakoshi Takayuki, Shimada Akira,◎ Inoue Ikuo
発行年月	2021/07/09
概要	PPARγ1 is highly expressed in the late-stage placenta, but its role is unknown yet. Pparγ1−/− conceptuses produced mature placentas with impaired vascularization. This was due to the loss of PPARγ1 in sinusoidal trophoblast giant cells (TGCs). The nuclei of the Pparγ1−/− TGCs were huge with excess endocycling. PPARγ1 may coordinate to exit endocycling and allow the terminal differentiation.
DOI	10.1016/j.ydbio.2021.07.003
PMID	34246625