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オバタ ヒデアキ
OBATA Hideaki
小幡 英章 所属 埼玉医科大学 医学部 総合医療センター 麻酔科（麻酔科、産科麻酔科） 職種 教授 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Repeated Administration of Duloxetine Suppresses Neuropathic Pain by Accumulating Effects of Noradrenaline in the Spinal Cord |
| 掲載誌名 | 正式名：Anesthesia and Analgesia ISSNコード：15267598 |
| 出版社 | Lippincott Williams and Wilkins |
| 巻・号・頁 | 126(1),298-307頁 |
| 著者・共著者 | Sachiko Ito,Takashi Suto,Shigeru Saito,Hideaki Obata |
| 発行年月 | 2018/01 |
| 概要 | BACKGROUND: Antidepressants are used to treat neuropathic pain and although the detailed mechanisms of their effects are unclear, the descending noradrenergic inhibitory system might play an important role. We tested our hypothesis that repeated administration of duloxetine suppresses neuropathic pain by restoringthe descending noradrenergic inhibitory system in rats 6 weeks after spinal nerve ligation (SNL). METHODS: We subcutaneously injected SNL rats with duloxetine (10 mg kg-1 day-1) daily for 3 consecutive days and assessed behavioral hypersensitivity and noxious stimulus-induced analgesia (NSIA) activated by subcutaneous injection of capsaicin. We also performed microdialysis studies of the spinal cord, noradrenaline measurements of homogenized lumbar spinal tissue, and immunohistochemistry of the locus coeruleus. RESULTS: Three daily injections of duloxetine attenuated the mechanical hyperalgesia induced by SNL (SNL treated with vehicle: 88 ± 9.4 g versus SNL treated with duloxetine: 148 ± 13 g, P<.001 estimated treatment effect of duloxetine [95% confidence interval {CI}], 65 [50.6-79.4]n = 6/group, on day 4) and recovered the decreased NSIA (vehicle: 154 ± 10 g |
| DOI | 10.1213/ANE.0000000000002380 |
| PMID | 28787337 |