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オバタ ヒデアキ
OBATA Hideaki
小幡 英章 所属 埼玉医科大学 医学部 総合医療センター 麻酔科（麻酔科、産科麻酔科） 職種 教授 |
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| 論文種別 | 学術雑誌(原著) |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Endogenous analgesic effect of pregabalin: A double-blind and randomized controlled trial |
| 掲載誌名 | 正式名：European Journal of Pain (United Kingdom) ISSNコード：15322149 |
| 出版社 | Blackwell Publishing Ltd |
| 巻・号・頁 | 21(6),997-1006頁 |
| 著者・共著者 | S. Sugimine,S. Saito,T. Araki,K. Yamamoto,H. Obata |
| 発行年月 | 2017/07 |
| 概要 | Background: Conditioned pain modulation (CPM) is widely used to measure endogenous analgesia, and a recent study indicated that drugs that act on endogenous analgesia are more effective in individuals with lower CPM. Recent animal studies have indicated that pregabalin activates endogenous analgesia by stimulating the descending pain inhibitory system. The present study examined whether the analgesic effect of pregabalin is greater in individuals with lower original endogenous analgesia using CPM. Methods: Fifty-nine healthy subjects were randomly assigned to either a pregabalin group or a placebo group, and 50 of them completed the study. CPM was measured before and after pregabalin or placebo administration. The correlation of initial CPM to change in CPM was compared between the pregabalin and placebo groups. Results: Initial CPM was significantly correlated with the change in CPM in the pregabalin group (r = −0.73, p < 0.0001) but not in the placebo group (p = 0.56) (difference in correlation coefficients between groups p = 0.004). Furthermore, the initial CPM significantly affected the change in CPM in the pregabalin group but not in the placebo group (pregabalin |
| DOI | 10.1002/ejp.1007 |
| PMID | 28169487 |