オバタ　ヒデアキ   OBATA Hideaki   小幡　英章    所属   埼玉医科大学  医学部 総合医療センター　麻酔科（麻酔科、産科麻酔科）    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Brain morphological alternation in chronic pain patients with neuropathic characteristics
掲載誌名	正式名：MOLECULAR PAIN ISSNコード：17448069
出版社	SAGE PUBLICATIONS INC
巻・号・頁	12,12頁
著者・共著者	Satomi Sugimine,Yuichi Ogino,Hiroaki Kawamichi,Hideaki Obata,Shigeru Saito
発行年月	2016/06
概要	Background: Neuropathic characteristics are highly involved in the development of chronic pain both physically and psychologically. However, little is known about the relationship between neuropathic characteristics and brain morphological alteration.Objectives: The aim of this study is to investigate the mechanisms of chronic pain development by examining the abovementioned relationships by voxel-based morphometry in patients with chronic pain.Methods: First, we assessed neuropathic characteristics using the painDETECT Questionnaire in 12 chronic pain patients. Second, to assess the gray matter volume changes by voxel-based morphometry, we conducted magnetic resonance imaging of the brain. We applied multiregression analysis of these two assessment methods.Results: There were significant positive correlations between painDETECT Questionnaire scores and the gray matter volume in the bilateral anterior cingulate cortex and right posterior cingulate cortex.Conclusions: Our findings suggest that neuropathic characteristics strongly affect the brain regions related to modulation of pain in patients with chronic pain and, therefore, contribute to the severity of chronic pain.
DOI	10.1177/1744806916652408
PMID	27284013