オバタ　ヒデアキ   OBATA Hideaki   小幡　英章    所属   埼玉医科大学  医学部 総合医療センター　麻酔科（麻酔科、産科麻酔科）    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Amitriptyline, but Not Pregabalin,Reverses the Attenuation of Noxious Stimulus-Induced Analgesia After Nerve Injury in Rats
掲載誌名	正式名：ANESTHESIA AND ANALGESIA ISSNコード：00032999
出版社	LIPPINCOTT WILLIAMS&WILKINS
巻・号・頁	123(2),504-510頁
著者・共著者	Hiroaki Matsuoka,Takashi Suto,Shigeru Saito,Hideaki Obata
発行年月	2016/08
概要	BACKGROUND: Noxious stimulus-induced analgesia (NSIA) is a type of conditioned pain modulation in rats that has been used to assess endogenous pain control systems. The descending noradrenergic system is involved in NSIA, and nerve injury induces plastic changes of descending noradrenergic neurons. Thus, we hypothesized that nerve injury would affect NSIA strength and that amitriptyline and pregabalin, which often are used for treating neuropathic pain, might further modulate NSIA through effects on the descending noradrenergic system.METHODS: We examined the change in NSIA over time after right L5 spinal nerve ligation (SNL) in rats by measuring the contralateral hind paw withdrawal threshold after left forepaw capsaicin injection. In addition, we examined NSIA after 5 daily intraperitoneal injection of amitriptyline or pregabalin. Microdialysis studies were performed to measure noradrenaline levels after left forepaw capsaicin injection in the left spinal dorsal horn in noninjured rats, SNL rats, and SNL rats that had received 5 daily intraperitoneal injections of amitriptyline or pregabalin.RESULTS: NSIA was dramatically attenuated 5 and 6 weeks after SNL (P< 0.001). The n
DOI	10.1213/ANE.0000000000001301
PMID	27088996