オバタ　ヒデアキ   OBATA Hideaki   小幡　英章    所属   埼玉医科大学  医学部 総合医療センター　麻酔科（麻酔科、産科麻酔科）    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	A randomized placebo-controlled study of preoperative pregabalin for postoperative analgesia in patients with spinal surgery
掲載誌名	正式名：JOURNAL OF CLINICAL ANESTHESIA ISSNコード：09528180
出版社	ELSEVIER SCIENCE INC
巻・号・頁	31,149-153頁
著者・共著者	Nao Fujita,Masaru Tobe,Noboru Tsukamoto,Shigeru Saito,Hideaki Obata
発行年月	2016/06
概要	Study objective: To determine whether single preoperative administration of 2 different doses of pregabalin (75 and 150 mg) could decrease postoperative pain intensity and opioid consumption following posterior lumbar interbody fusion surgery.Design: Prospective, randomized, active placebo-controlled, double-blinded study.Setting: Postoperative recovery area and patients' room.Patients: Ninety-seven adult, American Society of Anesthesiologists physical status 1 and 2 patients.Interventions: Patients were randomly assigned to receive diazepam 5 mg as an active placebo (D5), pregabalin 75 mg (P75), or pregabalin 150 mg (P150). The study drug was orally administered 2 hours prior to surgery and a standard anesthetic technique was used. Postoperative pain was managed using intravenous patient-controlled analgesia with morphine.Measurement: The visual analog scale at rest was used to measure pain intensity immediately after extubation at the postanesthesia care unit, and then 2, 4, 6, 12, 18, 24, 36, and 48 hours after surgery. Morphine consumption and adverse effects were assessed until 48 hours after surgery. Main results: The visual analog scale score at rest was lower in the P1
DOI	10.1016/j.jclinane.2016.01.010
PMID	27185699