オバタ　ヒデアキ   OBATA Hideaki   小幡　英章    所属   埼玉医科大学  医学部 総合医療センター　麻酔科（麻酔科、産科麻酔科）    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	The Antihyperalgesic Effects of Intrathecal Bupropion, a Dopamine and Noradrenaline Reuptake Inhibitor, in a Rat Model of Neuropathic Pain
掲載誌名	正式名：ANESTHESIA AND ANALGESIA ISSNコード：00032999
出版社	LIPPINCOTT WILLIAMS&WILKINS
巻・号・頁	120(2),460-466頁
著者・共著者	Hajime Hoshino,Hideaki Obata,Kunie Nakajima,Rie Mieda,Shigeru Saito
発行年月	2015/02
概要	BACKGROUND: Antidepressants are often used for the treatment of neuropathic pain, and their analgesic effects rely on increased noradrenaline and serotonin levels in the spinal cord. Clinical studies have also shown that bupropion, a dopamine and noradrenaline reuptake inhibitor, has strong efficacy in neuropathic pain; however, the role of spinal cord dopamine in neuropathic pain is unknown. We hypothesized that bupropion inhibits neuropathic pain by increasing noradrenaline and dopamine in the spinal cord. In the present study, we determined the efficacy and underlying mechanisms of intrathecal administration of bupropion in a rat model of neuropathic pain.METHODS: Male Sprague-Dawley rats were anesthetized, and right L5 spinal nerve ligation (SNL) was performed to produce mechanical hyperalgesia of the hindpaw. Withdrawal threshold to a paw pressure test was measured before and after intrathecal administration of bupropion, without or with intrathecal antagonists for alpha(2)-adrenoceptors and dopamine D-2 receptors. In vivo microdialysis was performed in the dorsal horn of the lumbar spinal cord to measurenoradrenaline and dopamine concentrations after intrathecal injection o
DOI	10.1213/ANE.0000000000000540
PMID	25427287