オバタ　ヒデアキ   OBATA Hideaki   小幡　英章    所属   埼玉医科大学  医学部 総合医療センター　麻酔科（麻酔科、産科麻酔科）    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Long-term effect of epidural injection with sustained-release lidocaine particles in a rat model of postoperative pain
掲載誌名	正式名：BRITISH JOURNAL OF ANAESTHESIA ISSNコード：00070912
出版社	OXFORD UNIV PRESS
巻・号・頁	109(6),957-967頁
著者・共著者	T. Suto,H. Obata,M. Tobe,H. Oku,H. Yokoo,Y. Nakazato,S. Saito
発行年月	2012/12
概要	Single applications of sustained-release local anaesthetics may provide prolonged pain relief without requiring indwelling catheters, but have not yet been investigated for epidural postoperative pain management. We synthesized injectable sustained-release lidocaine particles (SRLPs) from biodegradable polymers and examined their effect in a rat model of postoperative pain.Two types of polylactic acid particles, SRLP-10 and SRLP-25, containing 10 or 25 lidocaine, respectively, were generated and the lidocaine release was evaluated in vitro for 14 days. The SRLPs were then injected epidurally in the male SpragueDawley rats immediately before they received a hindpaw incision (the postoperative pain model), and hindpaw hypersensitivity was evaluated with the von Frey test. Motor paralysis and coordination were also assessed using a paralysis score and rota-rod test. Neurotoxicity and inflammation of the spinal cord, cauda equina, and tissue surrounding the injection site were histologically evaluated.In vitro, SRLP-10 and SRLP-25 released lidocaine over 7 and 3 days, respectively. The in vivo injection of SRLP-10 (80 mg) produced anti-hypersensitivity with no evidence of motor paral
DOI	10.1093/bja/aes302
PMID	22923636