オバタ　ヒデアキ   OBATA Hideaki   小幡　英章    所属   埼玉医科大学  医学部 総合医療センター　麻酔科（麻酔科、産科麻酔科）    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Antihypersensitivity Effects of Tramadol Hydrochloride in a Rat Model of Postoperative Pain
掲載誌名	正式名：ANESTHESIA AND ANALGESIA ISSNコード：00032999
出版社	LIPPINCOTT WILLIAMS&WILKINS
巻・号・頁	115(2),443-449頁
著者・共著者	Masafumi Kimura,Hideaki Obata,Shigeru Saito
発行年月	2012/08
概要	BACKGROUND: Tramadol is used to treat a wide range of acute and chronic pain. This drug induces analgesia by 2 mechanisms of action: opioid receptor activation and enhancement of noradrenaline (NA) and serotonin (5-HT) transmission. The effect of tramadol on NA and 5-HT concentrations in the spinal cord, however, have not been assessed. In the present study, we investigated the antihypersensitivity effect of tramadol using a rat model of postoperative pain. We also evaluated the increase in NA and 5-HT levels in the spinal cord after tramadol injection using in vivo microdialysis.METHODS: We made a hindpaw incision in male Sprague-Dawley rats (postoperative pain model). Tramadol was administered intraperitoneally and intrathecally 24 hours after paw incision. Mechanical hypersensitivity was measured by determining the withdrawal threshold using von Frey filaments. Microdialysis studies from the dorsal horn of the lumbar spinal cord were performed to measure NA and 5-HT levels after intraperitoneal injection of tramadol. We also measured the NA and 5-HT content in the spinal cord in normal rats and rats with paw incision.RESULTS: Intraperitoneal (10, 20, and 40 mg/kg) and intrathe
DOI	10.1213/ANE.0b013e31825683c3
PMID	22575568