オバタ　ヒデアキ   OBATA Hideaki   小幡　英章    所属   埼玉医科大学  医学部 総合医療センター　麻酔科（麻酔科、産科麻酔科）    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	An increase in spinal cord noradrenaline is a major contributor to the antihyperalgesic effect of antidepressants after peripheral nerve injury in the rat
掲載誌名	正式名：PAIN ISSNコード：03043959
出版社	ELSEVIER SCIENCE BV
巻・号・頁	153(5),990-997頁
著者・共著者	Kunie Nakajima,Hideaki Obata,Nobuhisa Iriuchijima,Shigeru Saito
発行年月	2012/05
概要	Antidepressants are often used for the treatment of neuropathic pain. Clinical studies suggest that the efficacy of serotonin (5-HT) and noradrenaline (NA) reuptake inhibitors (SNRIs) for neuropathic pain is greater than that of selective 5-HT reuptake inhibitors (SSRIs). In the present study, we determined the efficacy and mechanisms involved in the antihyperalgesic effects of milnacipran, an SNRI, compared with paroxetine, an SSRI, and maprotiline, a selective NA reuptake inhibitor, using a rat model of neuropathic pain. Male Sprague-Dawley rats underwent spinal nerve ligation (SNL), and the withdrawal threshold to paw pressure was measured. Intraperitoneal injection of milnacipran (3-30 mg/kg) produced a dose-dependent antihyperalgesic effect. The effect was reversed by intrathecal injection of the a2-adrenoceptor antagonist idazoxan (30 mu g), but not by various 5-HT receptor antagonists. Paroxetine produced an antihyperalgesic effect only at the highest dose tested (10 mg/kg). This effect was reversed by intrathecal injection of both idazoxan and ondansetron (30 mu g), a 5-HT3 receptor antagonist. Maprotiline produced an antihyperalgesic effect (10 and 30 mg/kg), and the effec
DOI	10.1016/j.pain.2012.01.029
PMID	22424692