オバタ　ヒデアキ   OBATA Hideaki   小幡　英章    所属   埼玉医科大学  医学部 総合医療センター　麻酔科（麻酔科、産科麻酔科）    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Activation of astrocytes in the spinal cord contributes to the development of bilateral allodynia after peripheral nerve injury in rats
掲載誌名	正式名：BRAIN RESEARCH ISSNコード：00068993
出版社	ELSEVIER SCIENCE BV
巻・号・頁	1363,72-80頁
著者・共著者	Hideaki Obata,Shinobu Sakurazawa,Masafumi Kimura,Shigeru Saito
発行年月	2010/12
概要	Activation of spinal cord microglia and astrocytes after peripheral nerve injury contributes to the development of behavioral hypersensitivity Suppression of spinal cord glial activation attenuates the development of nerve injury induced allodynia The contribution of spinal cord glia to existing allodynia however, is not known We investigated whether intrathecally administered propentofylline a glial inhibitor reverses existing allodynia after nerve injury Male Sprague-Dawley rats underwent L5 spinal nerve transection and mechanical allodynia was assessed by measuring hind paw withdrawal thresholds bilaterally using von Frey filaments Rats received either saline or propentofylline (1 3, and 10 mu g/d) for 7 days (days 0-7) by intrathecal infusion with an osmotic minipump Other groups of rats received either intrathecal infusion of saline or propentofylline (10 mu g/d) for 7 days on days 14-21 or 60-67 after surgery After completing the intrathecal infusion lumbar spinal cord sections were assessed for immunostaining of astrocytic glial fibrillary acidic protein and microglial OX 42 Propentofylline infusion on days 0-7 suppressed development of allodynia in both the ipsilateral and
DOI	10.1016/j.brainres.2010.09.105
PMID	20932955