オバタ　ヒデアキ   OBATA Hideaki   小幡　英章    所属   埼玉医科大学  医学部 総合医療センター　麻酔科（麻酔科、産科麻酔科）    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Lack of analgesic efficacy of spinal ondansetron on thermal and mechanical hypersensitivity following spinal nerve ligation in the rat
掲載誌名	正式名：BRAIN RESEARCH ISSNコード：00068993
出版社	ELSEVIER SCIENCE BV
巻・号・頁	1352,83-93頁
著者・共著者	Christopher M. Peters,Ken-ichiro Hayashida,Eric E. Ewan,Kunie Nakajima,Hideaki Obata,Qinghao Xu,Tony L. Yaksh,James C. Eisenach
発行年月	2010/09
概要	The balance between descending inhibition and facilitation is thought to be disturbed in chronic pain states. Increased facilitation by spinally released serotonin has been suggested by demonstration that mechanically evoked neuronal responses of wide dynamicrange neurons are inhibited by 5-HT3 receptor antagonists in rats following spinal nerve ligation (SNL) but not sham operation. Despite these physiologic data, the effects of spinal 5-HT3 receptor blockade on behavioral hypersensitivity and neurochemical alterations in spinal serotonergic system have not been thoroughly investigated following spinal nerve ligation in the rat. To test this, we acutely injected intrathecal ondansetron in rats between 14 and 30 days after SNL and assessed effects on thermal and mechanical hypersensitivity. We also determined the density of serotonergic nerve fibers, serotonin content and the levels of 5-HT3 receptors within the spinal cord at this time point. Intrathecal ondansetron (1, 3, 10, 30, and 100 mu g) produced no effect on behavioral measures of thermal or mechanical hypersensitivity whereas intrathecal morphine (1 mu g) and gabapentin (200 mu g) partially reversed thermal and mechanica
DOI	10.1016/j.brainres.2010.07.020
PMID	20637741