オバタ　ヒデアキ   OBATA Hideaki   小幡　英章    所属   埼玉医科大学  医学部 総合医療センター　麻酔科（麻酔科、産科麻酔科）    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	Monoamine-Dependent, Opioid-Independent Antihypersensitivity Effects of Intrathecally Administered Milnacipran, a Serotonin Noradrenaline Reuptake Inhibitor, in a Postoperative Pain Model in Rats
掲載誌名	正式名：JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS ISSNコード：00223565
出版社	AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
巻・号・頁	334(3),1059-1065頁
著者・共著者	Hideaki Obata,Masafumi Kimura,Kunie Nakajima,Masaru Tobe,Koichi Nishikawa,Shigeru Saito
発行年月	2010/09
概要	The neurotransmitters serotonin (5-HT) and noradrenaline (NA) have important roles in suppressing nociceptive transmission in the spinal cord. In the present study, we determined the efficacy and nature of the antihypersensitivity effects of milnacipran, a 5-HT and NA reuptake inhibitor (SNRI), in the spinal cord in a rat model of postoperative pain. Sprague-Dawley rats were used in all experiments. An incision was made on the plantar aspect of the hind paw. Mechanical hypersensitivity was measured by determining the withdrawal threshold to von Frey filaments applied to the paw. Drugs were administered intrathecally 24 h after paw incision. Microdialysis studies of the dorsal horn of the lumbar spinal cord were also performed to measure 5-HT and NA levels after systemic injection of milnacipran. Milnacipran (1-30 mu g) produced dose-dependent antihypersensitivity effects. The effect lasted 6 h after the 30-mu g injection. Doses of 30 mu g or less produced no abnormal behavior. The peak antihypersensitivity effect of 10 mu g of milnacipran was blocked by intrathecal pretreatment with antagonists of the mu 2-adrenoceptor (idazoxan; 30 mu g) or 5-HT receptors (methysergide; 30 mu g).
DOI	10.1124/jpet.110.168336
PMID	20558774