オバタ　ヒデアキ   OBATA Hideaki   小幡　英章    所属   埼玉医科大学  医学部 総合医療センター　麻酔科（麻酔科、産科麻酔科）    職種   教授
論文種別	学術雑誌(原著)
言語種別	英語
査読の有無	査読あり
表題	The nociceptive mechanism of 5-hydroxytryptamine released into the peripheral tissue in acute inflammatory pain in rats
掲載誌名	正式名：EUROPEAN JOURNAL OF PAIN ISSNコード：10903801
出版社	ELSEVIER SCI LTD
巻・号・頁	13(5),441-447頁
著者・共著者	Kunie Nakajima,Hideaki Obata,Naomi Ito,Fumio Goto,Shigeru Saito
発行年月	2009/05
概要	The present study examined the contribution of 5-hydroxytryptamine (5-HT) to acute peripheral inflammatory pain in rats. We used formalin test in this Study. After formalin injection into the rat hind paw, biphasic pain-related behavior (phases I and 2) was observed. A microdialysis study revealed that 5-HT was released into the formalin injection site in a formalin concentration-dependent manner (1.25-5%), and its peak time was 18 min after the injection. Previous studies suggest that peripheral 5-HT2 receptors are involved in inflammatory pain. Therefore. we next examined whether 5-HT2A and 5-HT2C receptors are involved, and from where 5-HT is released in the formalin test. Local pretreatment with a selective 5-HT2A receptor antagonist, ketanserin, and selective 5-HT2C receptor antagonists, RS102221 and SB242084, inhibited the number of flinches in early part of phase 2(phase 2A) of the formalin test in a dose-dependent manner. peripheral pretreatment with sodium cromoglycate (cromolyn). a mast cell membrane stabilizer, completely Suppressed 5-HT release and inhibited phase 2 responses of the formalin test. These drugs inhibited c-fos expression in the superficial layer of the s
DOI	10.1016/j.ejpain.2008.06.007
PMID	18656400